Huntington’s Disease Essay -- Health Medical Medicine Essays

Huntingtons DiseaseHuntingtons distemper is a fatal inherited disorder characterized by slow gradatory nature changes, dementia, and choreiform movements. It is a progressive unsoundness its average onset is 30 to forty long time of age, and the duration of the unhealthiness is about ten to xx years with death as the outcome. It is known that for Huntingtons disease, there is a corruption of cholinergic and GABAergic neurons in the basal ganglia and the cerebral cortex. The etiology of hardiness jail cell death in Huntingtons disease is unknown. However, there is a new hypothesis implicating defects in mitochondrial energy metabolism as the pathology of Huntingtons disease. Huntingtons disease is an autosomal dominant disease. The genetic defect appears on the unmindful arm of the chromosome 4, and it is an extended repetition of the three nucleotide bases (cytosine, adenine, and thou CAG) that enroll for the amino acid glutamate. This disease affects men and women equa lly, and it usually appears aft(prenominal) the individuals construct married and had children. The children of an affected p bent sop up a 50% possibility of inheriting the disease. With the discovery of the defective gene, it is now possible to have an dead on target diagnosis before the onset of the disease. The early indications of Huntingtons disease are not prominent the individuals vex absentminded, easily irritated, and constantly depressed. Their storage is diminished, and they neglect spontaneity, initiative, and the ability to concentrate. There are also early tough signs of choreiform (dance-like) movements. The persons capture with piano-playing movements of the fingers or with slight facial twitching (Martin, 1984). The movements gradually become more than uncontrollable. ... ...s? Trends in Neurological Sciences, 16 (4) pp. 125-131. Choi, Dennis W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, pp.623-632. Prim, D. M., Simpson, J., Uhler, T. A., Short, M. P., Bossi, S. R., Breakefield, X. O., & Isacson, O. (1993). Striatal degeneration bring forth by mitochondrial blockade is prevented by biologically delivered NGF. Journal of Neuroscience interrogation, 35 pp. 452-458. Martin, Joseph B. (1984). Huntingtons disease New approaches to an old problem. Neurology, 34 pp. 1059-1071. Willard, Frank H. (1993). Medical Neuroanatomy A Problem- lie Manual with Annotated Atlas. Philadelphia J. B. Lippincott Company. Young, Anne B. (1993). Role of excitotoxins in heredito-degenerative neurologic diseases. Research Publications- joining for Research in Nervous and Mental Diseases, 71 pp. 175-189. Huntingtons Disease judge -- Health Medical Medicine EssaysHuntingtons DiseaseHuntingtons disease is a fatal inherited disorder characterized by slow gradual personality changes, dementia, and choreiform movements. It is a progressive disease its average onset is thirty to forty years of age, and the dura tion of the disease is about ten to twenty years with death as the outcome. It is known that for Huntingtons disease, there is a degeneration of cholinergic and GABAergic neurons in the basal ganglia and the cerebral cortex. The etiology of nerve cell death in Huntingtons disease is unknown. However, there is a recent hypothesis implicating defects in mitochondrial energy metabolism as the pathology of Huntingtons disease. Huntingtons disease is an autosomal dominant disease. The genetic defect appears on the short arm of the chromosome 4, and it is an extended repetition of the three nucleotide bases (cytosine, adenine, and guanine CAG) that code for the amino acid glutamate. This disease affects men and women equally, and it usually appears after the individuals have married and had children. The children of an affected parent have a 50% chance of inheriting the disease. With the discovery of the defective gene, it is now possible to have an accurate diagnosis before the onset of the disease. The early indications of Huntingtons disease are not prominent the individuals become absentminded, easily irritated, and constantly depressed. Their memory is diminished, and they lack spontaneity, initiative, and the ability to concentrate. There are also early subtle signs of choreiform (dance-like) movements. The persons begin with piano-playing movements of the fingers or with slight facial twitching (Martin, 1984). The movements gradually become more uncontrollable. ... ...s? Trends in Neurological Sciences, 16 (4) pp. 125-131. Choi, Dennis W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, pp.623-632. Prim, D. M., Simpson, J., Uhler, T. A., Short, M. P., Bossi, S. R., Breakefield, X. O., & Isacson, O. (1993). Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF. Journal of Neuroscience Research, 35 pp. 452-458. Martin, Joseph B. (1984). Huntingtons disease New approaches to an old problem. Neurology, 34 pp. 1059-1071. Willard, Frank H. (1993). Medical Neuroanatomy A Problem- Oriented Manual with Annotated Atlas. Philadelphia J. B. Lippincott Company. Young, Anne B. (1993). Role of excitotoxins in heredito-degenerative neurologic diseases. Research Publications- Association for Research in Nervous and Mental Diseases, 71 pp. 175-189.